Season
- Season 21 2013-01-02
- Season 20 2012-01-03
- Season 19 2011-01-03
- Season 18 2010-03-01
- Season 17 2008-06-02
- Season 16 2007-09-17
- Season 15 2006-09-18
- Season 14 2005-06-06
- Season 13 2004-06-07
- Season 12 2003-06-02
- Season 11 2002-06-03
- Season 10 2002-04-30
- Season 9 2000-08-01
- Season 8 1999-07-30
- Season 7 1998-02-26
- Season 6 1997-12-05
- Season 5 1996-09-16
- Season 4 1996-03-07
- Season 3 1994-11-28
- Season 2 1993-06-25
- Season 1 1992-05-25
- Season 0 2014-02-06
Episode
- Episode 1: Howie Mandel, Amanda Bynes, Emmylou Harris
- Episode 2: Jamie Foxx, Tim Gunn, Paolo Nutini
- Episode 3: Dane Cook, Ali Larter, LCD Soundsystem
- Episode 4: Jessica Alba, D.L. Hughley, Cold War Kids
- Episode 5: Hugh Laurie, Sherri Shepherd, The Editors
- Episode 6: Dwayne "The Rock" Johnson, Dennis Kucinich, Diana Krall
- Episode 7: Jennifer Love Hewitt, Jeff Corwin, Reba McEntire with Vince Gill
- Episode 8: Steve Carell, Madison Pettis, Bright Eyes
- Episode 9: Ben Stiller, Tony Snow, Raul Midon
- Episode 10: Teri Hatcher, Kevin McKidd, Queen Latifah
- Episode 11: Patricia Heaton, Emeril Lagasse, Tori Amos
- Episode 13: Tom Selleck, Carlos Mencia, Bobbie and Willie Nelson
- Episode 14: John Larroquette, Chelsea Handler, Matchbox Twenty
- Episode 15: Cate Blanchett, Tyler Perry, Annie Lennox
- Episode 16: Ben Affleck, Jim Norton, The Shins
- Episode 17: Jaime Pressly, Brady Barr, Blue Man Group
- Episode 18: Dana Carvey, Malin Akerman, Plain White T's
- Episode 19: Joaquin Phoenix, Gordon Ramsay, Vanessa Carlton
- Episode 20: Christina Applegate, Bill O'Reilly, Alicia Keys
- Episode 21: James Spader, Lara Logan, Steve Byrne
- Episode 22: Reese Witherspoon, David Koechner, PJ Harvey
- Episode 23: Sen. Barack Obama, Orny Adams, Keith Urban
- Episode 24: Jerry Seinfeld, Amy Ryan, Evanescence
- Episode 25: Halle Berry, Greg Grunberg, Dwight Yoakam
- Episode 26: Russell Crowe, Jenna Bush, Carrie Underwood
- Episode 27: Tom Cruise, Rep. Ron Paul, Sex Pistols
- Episode 28: Eva Mendes, Marjorie Johnson, Barry Manilow
- Episode 29: Denzel Washington, Dave Salmoni, LeAnn Rimes
- Episode 30: Steve Carell, Manny Ramirez, Backstreet Boys
- Episode 31: Gov. Mike Huckabee, Emeril Lagasse, Chingy
- Episode 32: Howie Mandel, Jason Lewis, Joe Nichols
- Episode 33: Animals With Jarod Miller, John Caparulo, Blake Lewis
- Episode 34: Ron Paul, Christopher Titus, Shakira
- Episode 35: Pamela Anderson, Mary J. Blige
- Episode 36: Jules Sylvester and animals, Maria Bartiromo, Finger Eleven
- Episode 37: Jimmy Kimmel, Elon Gold, OneRepublic
- Episode 38: Arsenio Hall, Melanie Metz & Peggy Willenberg, Seether
- Episode 39: Marilu Henner, Brady Barr, Jordan Sparks
- Episode 40: Bill Maher, Carrie Ann Inaba & Bruno Tonioli, Taylor Swift
- Episode 41: Chris Matthews, John Roy, Jill Scott
- Episode 42: D.L. Hughley, Joe Ligotti, Sara Bareilles
- Episode 43: Mitt Romney, Ryan Sheckler, Jonas Brothers
- Episode 44: Simon Cowell & Ryan Seacrest, Tavis Smiley, Shaggy
- Episode 45: David Gregory, Performing Birds, Puddle Of Mudd
- Episode 46: Adam Carolla, Richard Roeper, Shooter Jennings
- Episode 47: Animals With Julie Scardina, Chelsea Handler, Buckcherry
- Episode 48: Hulk Hogan, Mad Scientist David Willey, Natasha Bedingfield
- Episode 49: Chazz Palminteri, Alison Sweeney, Dierks Bentley
- Episode 50: Lester Holt, Blue Ribbon Baker Marjorie Johnson, Raheem DeVaughn
- Episode 51: Animals with Dave Salmoni, Tom Green, Maroon 5
- Episode 52: Sen. John McCain, Rudy Giuliani, Shelby Lynne
- Episode 53: Tom Brokaw, Terrell Owens, Graham Colton
- Episode 54: Dan Rather, Mike Rowe, Josh Kelley
- Episode 55: Insects with Brent Karner, Stephen Baldwin, J. Holiday
- Episode 56: Frank Caliendo, Chimp Rescuer Eugene Cussons, Flo Rida
- Episode 57: Arsenio Hall, Paula Deen, James Blunt
- Episode 58: Brian Williams, Ahmed Ahmed, Enrique Iglesias
- Episode 59: Larry the Cable Guy, Bobby Knight, Andrea Bocelli
- Episode 60: Larry the Cable Guy, Bruno Tonioli, Glen Hansard & Markéta Irglová
- Episode 61: Joan Embery and Animals, Larry the Cable Guy, Mika
- Episode 62: Russell Crowe, Larry the Cable Guy, Willie Nelson
- Episode 63: Kristen Chenoweth, Russell Peters, Lifehouse
- Episode 64: Reese Witherspoon, Alex Cambert, Gary Allan
- Episode 65: Will Ferrell, Hayden Christensen, The Hives
- Episode 66: Garth Brooks, Christina Ricci
- Episode 67: Heidi Klum, James McAvoy, John Fogerty
- Episode 68: Colin Farrell, Bill O'Reilly, Herbie Hancock
- Episode 69: Eric Bana, Catherine O'Hara, Tift Merritt
- Episode 70: Dennis Quaid, David Koechner, Lupe Fiasco
- Episode 71: Billy Ray Cyrus, Miley Cyrus, Brooke Shields
- Episode 72: Wanda Sykes, Bryan Cranston, Cat Power
- Episode 73: Dave Salmoni and Animals, Patricia Arquette, The Punch Brothers
- Episode 74: Dominic Monaghan, Ethan Bortnick, Sheryl Crow
- Episode 75: America Ferrera, Bob Saget, The Blind Boys of Alabama
- Episode 76: Bill Cosby, Novak Djokovic, Landon Pigg
- Episode 77: Howie Mandel, Minnie Driver
- Episode 78: Gordon Ramsay
- Episode 79: Kate Beckinsale, Carlos Mencia, The Bravery
- Episode 80: Terry Bradshaw, James Carville & Mary Matalin, Michael McDonald
- Episode 81: Ryan Phillippe, Lisa Lampanelli, Jim Lauderdale
- Episode 82: John Edwards, Leslie Mann, Nada Surf
- Episode 83: Adam Carolla, Geraldo Rivera, The Black Crowes
- Episode 84: Peter O'Toole, Katt Williams, Leona Lewis
- Episode 85: Abigail Breslin, Seth Meyers, Steve Earle
- Episode 86: John Krasinski, Joe Torre, José González
- Episode 87: Conan O'Brien, Anderson Cooper, Allison Moorer
- Episode 88: John Larroquette, Kid Inventors, k.d. lang
- Episode 89: Jodie Foster, Cedric the Entertainer, Lili Haydn
- Episode 90: Mike Huckabee; Emeril Lagasse; Chingy
- Episode 91: Steve Carell, Kathie Lee Gifford, Ani DiFranco
- Episode 92: Sen. Hillary Clinton, Patton Oswalt, Ferras
- Episode 93: David Spade, Nora Hardwick, Ben Lee
- Episode 94: Pamela Anderson; Mary J. Blige
- Episode 95: Jules Sylvester; Maria Bartiromo; Finger Eleven
- Episode 96: Jimmy Kimme; Elon Gold; OneRepublic
- Episode 97: Keanu Reeves, Chelsea Handler, The Redwalls
- Episode 98: William Shatner, Tricia Helfer, Ryan Bingham
- Episode 99: Mark Harmon, Corbin Maxey, Ray J
- Episode 100: Brad Garret; Ingrid Michaelson; John Melendez
- Episode 101: Charles Barkley, The Young@Heart Chorus
- Episode 102: Ewan McGregor, John Cho & Kal Penn, Seether
- Episode 103: Tracey Ullman, Jason Taylor, Flogging Molly
- Episode 104: Dave Salmoni, Norm MacDonald, Ashlee Simpson
- Episode 105: Julia Louis-Dreyfus, Jason Segel, Goldfrapp
- Episode 106: Patrick Dempsey, Ed Begley Jr., Tegan and Sara
- Episode 107: Gov. Arnold Schwarzenegger, Marilu Henner, Old 97's
- Episode 108: Hugh Laurie, Doug Fine, Prince
- Episode 109: Helen Hunt, Gov. Bobby Jindal, Duffy
- Episode 110: Dr. Phil McGraw, the Lopez family, Natasha Bedingfield
- Episode 111: Cindy McCain, Ed Helms, Augustana
- Episode 112: Robin Williams, Terrence Howard, Serj Tankian
- Episode 113: Sally Field, Jesse Ventura, Sleepercar
- Episode 114: Robert Downey Jr., Carlos Mencia, Rascal Flatts
- Episode 115: Julie Scardina and animals, Christina Ricci, KT Tunstall
- Episode 116: Former President Jimmy Carter, Jon Favreau, P.O.D.
- Episode 117: Jenna Fischer, Robert Schimmel, Trace Adkins
- Episode 118: Harrison Ford, William Moseley, Carly Simon
- Episode 119: Jack Black, Clay Aiken
- Episode 120: Evangeline Lilly, Ben Barnes, Switchfoot
- Episode 121: Rainn Wilson, Howard Dean, Kate Nash
- Episode 122: Dana Delany, Adam Carolla, Dwight Yoakam
- Episode 123: Matthew Fox, Kathleen Edwards
- Episode 124: Simon Cowell, Rob Schneider, Josh Groban
- Episode 125: Sylvester Stallone, Irma & Ray Ziff, Jason Mraz
- Episode 126: Adam Sandler, Hilary Duff, Al Green
- Episode 127: Laura & Jenna Bush, David Cook, Tristan Prettyman
- Episode 128: Terry Bradshaw, Turkey Baster Virtuoso Ray Sanders, Colbie Caillat
- Episode 129: William Shatner, Chelsea Handler, Newton Faulkner
- Episode 130: Liv Tyler, Judd Apatow, Usher
- Episode 131: Jeff Foxworthy, Arianna Huffington, N.E.R.D.
- Episode 132: Dave salmoni; Patricia Arquette; Punch Brothers
- Episode 133: Will Smith, Pete Sampras, Ed Harcourt
- Episode 134: Russel Brand, Bill Engvall, Aimee Mann
- Episode 135: Justin Timberlake, Karen Allen, Sheryl Crow
- Episode 136: Dana Carvey, Spencer Breslin, Priscilla Ahn
- Episode 137: Mike Myers, Abigail Breslin, David Cook
- Episode 138: Larry the Cable Guy, Bob Costas, Ashanti
- Episode 139: Anne Hathaway; Gabriel Iglesias; Amos Lee
- Episode 140: Ryan Phillippe; Lisa Lampanelli; Jim Lauderdale
- Episode 141: Dwayne "The Rock" Johnson, Tom Papa, Against Me!
- Episode 142: Wanda Sykes, James McAvoy, Duffy
- Episode 143: Bette Midler, Al Roker
- Episode 144: Selma Blair, Kevin Nealon, Steve Tyrell
- Episode 145: Aaron Eckhart, Dara Torres, Los Lonely Boys
- Episode 146: Animal Expert Jarod Miller, David Koechner, Sara Bareilles
- Episode 147: Conan O'Brien; Anderson Cooper; Allison Moorer
- Episode 148: John Larroquette; Kid Inventors; K.D. Lang
- Episode 149: Jodie Foster; Cedric the Entertainer; Lili Hayden
- Episode 150: David Beckham; Sherri Shepherd; B-52s
- Episode 151: Steve Carell; Kathie Lee Gifford; Ani LiFranco
- Episode 152: Hillary Clinton; Patto Oswalt; Ferras
- Episode 153: David Spade; Nora Hardwick; Ben Lee
- Episode 154: Thomas Haden Church; Sig & Edgar Hansen; Jimmy Eat World
- Episode 155: Dennis Quaid; Russell Brand; Brett Dennen
- Episode 156: Ellen Page; Donny & Marie Osmond; Angie Stone
- Episode 157: Keanu Reeves; Chelsea Handler; The Redwalls
- Episode 158: William Shatner; Tricia Helfer; Ryan Bingham
- Episode 159: Mark Harmon; Corbin Maxey; Ray J
- Episode 160: Brad Garrett; John Melendez; Ingrid Michaelson
- Episode 161: Charles Barkley; Young @ Heart Chorus
- Episode 162: Rosie Perez, Robin Thicke
- Episode 163: Bill Cosby, Emma Stone, John Mellencamp with T Bone Burnett
- Episode 164: Ben Stiller, Jonas Brothers
- Episode 165: Robert Downey Jr., Anna Faris, Toby Keith
- Episode 166: Jack Black, Pillsbury Bake-Off-Champ Carolyn Gurtz, Conor Oberst
- Episode 167: Nick Nolte, Carrot Top, Solomon Burke
- Episode 168: Hugh Laurie; Doug Fine; Prince
- Episode 169: Sen. John McCain, Dara Torres, Juliana Hatfield
- Episode 170: Norm MacDonald, Nastia Liukin, B.B. King
- Episode 171: Bill Maher, Henry Cejudo, Low vs Diamond
- Episode 172: Gordon Ramsay, Natalie Coughlin, Missy Higgins
- Episode 173: Arsenio Hall, Shawn Johnson, Chuck Berry
- Episode 174: Russell Brand, Eva Longoria Parker, Ingrid Michaelson
- Episode 175: Billy Bob Thornton, Ethan Bortnick, Brian Wilson
- Episode 176: Howie Mandel, Sanya Richards, The Game
- Episode 177: Jenna Fischer; Robert Schimmel; Trace Adkins
- Episode 178: Harrison Ford; William Moseley; Carly Simon
- Episode 179: Jules Sylvester, Annette Bening, Leona Lewis
- Episode 180: Matthew McConaughey, T. Boone Pickens, Al Green
- Episode 181: Jamie Lee Curtis, Jerome Bettis, Alejandro Escovedo
- Episode 182: Hugh Laurie, Dame Edna, Raphael Saadiq
- Episode 183: Matthew Fox; Kathleen Edwards
- Episode 184: Simon Cowell; Rob Schneider; Josh Groban
- Episode 185: Sylvester Stallone; Irma & Ray Ziff; Jason Mraz
- Episode 186: Adam Sandler; Hillary Duff; Al Green
- Episode 187: Laura & Jenna Bush; David Cook; Tristan Prettyman
- Episode 188: Terry Bradshaw; Ray Sanders; Colbie Caillat
- Episode 194: Ellen Degeneres; Jerry O'Connell; Jazmine Sullivan
The Tonight Show with Jay Leno Season 16 Ron Paul, Christopher Titus, Shakira
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